The first hearings take place in Edinburgh on Wednesday and are expected to last several weeks.
Faith based organizations as well residential and foster care providers are due to give evidence as well as expert witnesses, the Scottish Government and survivors.
It will cover a period within living memory of anyone who suffered such abuse, no later than 17th December 2014.
The inquiry aims to establish to what extent institutions and bodies with legal responsibility for the care of children failed in their duty to protect children in care in Scotland, as well as seek to identify any systemic failures in fulfilling that duty.